Spirion uses the Exchange services page https://ExchangeLocation/ews/exchange.asmx page.
Among the many other data repositories that Spirion searches (Dropbox, Amazon Cloud Drive, Microsoft Office 365 "Exchange", Google Drive, Box Sync, etc.) this includes Exchange on-premise and off premise deployments.
Spirion uses a process to query an Exchange services page /ews/exchange.asmx that all Exchanges services sites provide out of the box. This Exchange page provides functionality to connect to and examine information for Exchange. More information about this Spirion integration is located at http://my.spirion.com/Help/EnterpriseConsole/index.htm#3392.htm?Highlight=exchange for the console.
To begin the Spirion search of a Exchange site verify that you are able to open the Exchange site that the list service is running, for example - https://outlook.office365.com/ews/exchange.asmx. The page service is always accessed by appending /ews/exchange.asmx to any root site.
Now that you can resolve the list data you can add this working URL to the Spirion console using these instructions - http://my.spirion.com/Help/EnterpriseConsole/index.htm#3392.htm?Highlight=exchange.